Crohn's Disease and Glutathione Depletion
Glutathione (GSH) is the main antioxidant of intestinal epithelial cells and glutathione depletion is known to cause mucosal inflammation in the gut. Studies have shown that glutathione levels are depleted in patients with Crohn's disease due to the high amount of oxidative stress present in the inflamed gut.
The presence of oxidative stress is further demonstrated by the elevated level of the oxidised (or 'used up') form of the antioxidant (GSSG).
Intestinal inflammation may be reversed by increasing glutathione (GSH) levels, to help neutralise the excessive oxidative stress and reduce inflammation.
The presence of oxidative stress is further demonstrated by the elevated level of the oxidised (or 'used up') form of the antioxidant (GSSG).
Intestinal inflammation may be reversed by increasing glutathione (GSH) levels, to help neutralise the excessive oxidative stress and reduce inflammation.
"Decreased activity of key enzymes involved in glutathione (GSH) synthesis accompanied by a decreased availability of cysteine for GSH synthesis contribute to mucosal GSH deficiency in Inflammatory Bowel Disease (IBD). As the impaired mucosal anti-oxidative capacity may further promote oxidative damage, GSH deficiency might be a target for therapeutic intervention in IBD." | 
Glutathione (GSH) is the most important intestinal antioxidant
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Antioxidant Support to Reduce Gut Inflammation
Glutathione is a vital antioxidant for repairing and protecting intestinal health. It is known that glutathione levels are depleted in Crohn's disease and that enhanced glutathione levels are beneficial for intestinal health, but in practice it can be difficult to effectively increase systemic glutathione levels, as glutathione (GSH) is a fragile molecule that is quickly broken down in the digestive system if taken by mouth. Glutathione must be synthesised within the cells because it cannot be transported into cells.
The glutathione prodrug RiboCeine™ delivers the essential precursor nutrients (ribose and cysteine) to the cell where they can then be turned into glutathione and energy in the form of ATP. RiboCeine has received extensive scientific validation in published peer-reviewed studies and has been shown to dramatically increase intracellular glutathione production.
Advanced nutritional supplement Cellgevity™ contains RiboCeine along with a selection of natural antioxidant and anti-inflammatory ingredients, ideal for supporting digestive health and a healthy immune system.
Cellgevity also contains the botanical antioxidants resveratrol and curcumin which assist in reducing inflammation. Research shows that taking these compounds together creates a synergistic effect, making them potent tools for quenching the inflammation and damage in the small intestines and elsewhere in the body.
The glutathione prodrug RiboCeine™ delivers the essential precursor nutrients (ribose and cysteine) to the cell where they can then be turned into glutathione and energy in the form of ATP. RiboCeine has received extensive scientific validation in published peer-reviewed studies and has been shown to dramatically increase intracellular glutathione production.
Advanced nutritional supplement Cellgevity™ contains RiboCeine along with a selection of natural antioxidant and anti-inflammatory ingredients, ideal for supporting digestive health and a healthy immune system.
Cellgevity also contains the botanical antioxidants resveratrol and curcumin which assist in reducing inflammation. Research shows that taking these compounds together creates a synergistic effect, making them potent tools for quenching the inflammation and damage in the small intestines and elsewhere in the body.
order your cellgevity HERE
RiboCeine is a breakthrough nutrient compound of epic proportion that has been shown to effectively deliver the key precursor nutrient into the cell that enables it to produce optimal amounts of glutathione. Unlike any other nutritional compound in the world, RiboCeine has been the subject of twenty published, peer-reviewed scientific studies that were funded by the National Institues of Health and other scientific institutions. RiboCeine was developed by the world-renowned research scientist and medicinal chemist, Herbert T. Nagasawa, Ph.D. Dr. Nagasawa was a Professor of Medicinal Chemistry and Toxicology at the University of Minnesota for forty years and at the same time he was named Senior Career Research Scientist for the Veterans Administration in Minneapolis. For thirty-two of those years he was Senior Editor of the Journal of Medicinal Chemistry. Dr. Nagasawa now serves as the Executive Scientist for Max International. RiboCeine has significantly outperformed all other means of glutathione enhancement against which it has been tested.